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Investing.com -- Moderna Inc (NASDAQ:MRNA) slid 3% in premarket trading after William Blair downgraded the biotechnology company to Market Perform from Outperform, citing valuation constraints following a meteoric run. The downgrade follows a staggering 545% year-to-date rally, driven by a near-250% surge since August after encouraging Phase 3 INTERPATH-001 data for its personalized cancer vaccine candidate.

Moderna CEO Stéphane Bancel says the biotech’s competitive edge stems from its mRNA platform, likening it to software in Big Tech.

Moderna shares are trading lower Tuesday after William Blair downgraded the stock to Market Perform on Monday, citing valuation concerns.

William Blair analyst Myles Minter downgrades Moderna (NASDAQ:MRNA) from Outperform to Market Perform.

Moderna (NasdaqGS:MRNA) and Merck reported detailed Phase 3 data for their individualized mRNA melanoma vaccine plus KEYTRUDA, intismeran, at ESMO 2026. The Phase 3 trial showed a significant reduction in disease recurrence and distant metastasis in melanoma patients receiving the combination regimen. The intismeran results have been accepted for publication in The New England Journal of Medicine, adding peer reviewed validation for the program. The mRNA melanoma vaccine and KEYTRUDA Phase 3...

Moderna’s stock tanked Thursday following a data leak for the drugmaker’s cancer-vaccine candidate, which is co-developed with Merck.
Key TakeawaysModerna shares fell another 8% this morning. On Saturday it and its partner Merck presented full Phase 3 data showing their personalized melanoma vaccine cut the risk of recurrence or death by 42%.

2026-10-26. The following slide deck was published by Moderna, Inc.

Amgen showcases “excellent” data for its small-cell lung cancer treatment following leaked results for Moderna and Merck’s intismeran autogene.

Moderna stock yo-yoed Monday on more muted expectations for its Merck-partnered cancer vaccine, INT.

Moderna (NASDAQ:MRNA) presented Phase 3 results for intismeran, its individualized neoantigen therapy, in combination with Merck’s pembrolizumab for patients with resected high-risk melanoma. The INTerpath-001 trial met its primary endpoint of relapse-free survival and a key secondary endpoint of di

Moderna, Inc. (MRNA) Discusses Phase III Data for Intismeran and Advances in Cancer Immunotherapy October 24, 2026 1:00 PM EDTCompany ParticipantsDavid...

Moderna falls despite positive phase III cancer therapy data showing reduced melanoma recurrence and metastasis risks, as investors weigh elevated expectations.

The stock fell 17% in one trading session.

Moderna fell up to 25% despite a cancer vaccine that cut melanoma recurrence or death risk 42%, as expectations ran high.

Moderna spent much of 2025 caught between bullish hopes for mRNA expansion and bearish warnings about shrinking COVID demand and tighter pricing. For Moderna shareholders, the return over the past year was 671.9%, including dividends. If you had been weighing those sharply different analyst views in October 2025, how would you have judged the odds that such an extreme outcome could follow from the business that was on record then? The move put Moderna in the middle of this trade. Scan 36...
Shares of biotechnology company Moderna (NASDAQ:MRNA) fell 22.7% in the afternoon session after the company's partial Phase 3 data for its personalized cancer vaccine leaked ahead of a planned presentation this weekend, and the stock sold off hard even though the results themselves look positive. According to CNBC, shares fell as much as 25% after an early look at the vaccine Moderna is developing with Merck, intismeran autogene, showed up online before it was supposed to be presented at the Eur

Mizuho analyst Jared Holz said the vaccine data weren’t bad, but Wall Street’s expectations were too high.
Moderna shares tumbled after leaked cancer vaccine trial data showed promising results for its treatment developed with Merck.

Personalized cancer vaccine material allegedly circulated online ahead of formal Phase 3 results, today, Oct. 22, 2026.

Moderna shares are taking a hit after the leak of highly anticipated details about the company’s vaccine for the skin cancer melanoma.

Investors were awaiting full data from the late-stage trial of intismeran autogene plus Merck’s Keytruda at the European Society for Medical Oncology Congress on October 24.

The stock fell up to 25% even though the data that was leaked was positive in relation to Wall Street's expectations.

Leaked results from Moderna's melanoma vaccine trial have the stock challenging its worst day ever, while the rest of healthcare rallies.

Moderna shares tumbled as reported results for its cancer vaccine with Merck circulated ahead of a planned conference presentation.

Key TakeawaysModerna Inc. (NASDAQ:MRNA) sank as much as roughly 25% intraday after apparent Phase 3 results for its personalized melanoma vaccine surfaced online ahead of an embargoed medical-conference presentation.

Investing.com -- Moderna shares plunged more than 25% on Thursday, while Merck fell over 3%, after what appeared to be an early release of closely watched clinical trial results for the companies’ experimental cancer vaccine.

Moderna (MRNA) has just been added to the NASDAQ-100 Index. This move places the biotech company alongside some of the largest non-financial companies on the exchange and is drawing fresh attention to its shares. Recent trading has been strong, with Moderna’s share price delivering a 42.14% 1 month gain and a very large year to date share price return. The 1 year total shareholder return is also very large, pointing to powerful momentum following this NASDAQ-100 inclusion. See how Moderna’s...
The latest trading day saw Moderna (MRNA) settling at $245.81, representing a +1.54% change from its previous close.

MRNA expands beyond COVID-19 with new RSV, flu and combination vaccines, but fierce competition could challenge its efforts to diversify revenue.

A number of stocks jumped in the afternoon session after investors rotated into defensive assets and priced in rising expectations that midterm election outcomes could reverse recent federal spending cuts.

Moderna shares are trading higher Monday ahead of detailed Phase 3 melanoma data due Saturday and after BofA raised its price target.

Humacyte, Vera, Maze and Climb Bio will present dialysis-access and kidney-disease findings at ASN Kidney Week.

It was a head-turning headline. Here's why the market was buzzing.

BioNTech has billions in cash, and its oncology programs are moving into late-stage clinical trials.

Moderna was recently added to the Nasdaq-100 Index after positive Phase 3 data for its personalized cancer vaccine with Merck highlighted a pivot toward oncology beyond COVID-focused products. The late-stage success of intismeran positions Moderna's mRNA platform as a potential multi-product franchise across cancer and other conditions rather than a single-therapy story. Next, the focus turns to how this cancer vaccine progress could reshape Moderna's broader investment narrative around...
Moderna and Revolution Medicines have upcoming catalysts that could help sustain their gains, even as biotech stocks retreat.

A number of stocks fell in the afternoon session after capital-intensive growth equities experienced sharp sell-offs as elevated bond yields restricted market appetite for risk.

Moderna and Revolution Medicines have upcoming catalysts that could help sustain their gains, even as biotech stocks retreat.

Vaccine stocks are cracking under intense selling pressure, and one small developer with no control over its own commercial fate is bearing the worst of it. Whether its big-pharma partner can change that story is the question every shareholder now faces.

Moderna sank as Wall Street grew more cautious on the company's valuation after a massive rally this year.

Moderna stock is shedding 10% after a blistering cancer vaccine run, and the question now is whether profit takers know something the bulls don't ahead of a critical trial readout later this month.

National Cancer Institute’s director, Dr. Anthony Letai, wants a national effort behind the vaccines, The New York Times reported on Friday.

The biotech could play a significant role in a national effort to combat cancer.

Moderna shares on Friday were driven by multiple catalysts, including a Nasdaq-100 entry, a New York Times report on a planned NIH-backed cancer-vaccine push and a price target hike.

Why Everest Medicines Stock Is Back On Investors’ Radar Everest Medicines (SEHK:1952) just added two experienced mRNA cancer vaccine scientists, Lakshmi Srinivasan, PhD, and Brandon Coder, PhD, to help advance its AI+mRNA platform and upcoming clinical programs. Those hires come at a time when Everest Medicines’ share price has been volatile, with a 90 day share price return of 7.64%, a year to date share price return down 21.9%, and a 1 year total shareholder return down 44.36%. This points...

Moderna’s stock has taken a big hit that might signal the end of this year’s cancer vaccine-driven rally. It may not, however, be too late to play the forces behind its rise.

Moderna and Merck’s cancer vaccine reduced the risk of melanoma recurrence or death by 42%, but investors questioned its potential across other cancers.



Moderna shares tumbled as reported results for its cancer vaccine with Merck circulated ahead of a planned conference presentation.



Moderna (MRNA) stock has gained 282.6% over the past three months, outpacing a 4.1% return for the S&P 500. The shares reached their highest close in a year on October 15, 2026, ending the session at $236.50. Investors paying that premium are betting the drugmaker is ready to grow again. To meet those expectations, its sales, nearly all from COVID vaccines, have to stop shrinking, while its newer vaccines and cancer drugs have to start selling. Has the business caught up with Moderna's share pri

